Arthrotec (Diclofenac/Misoprostol)

TypeDrug NameDosagePrice from 
drug typeArthrotec50 mg/200 mcg$271.99
drug typeArthrotec75 mg/200 mcg$331.99

Generic Equivalent of Arthrotec

TypeDrug NameDosagePrice from 
drug typeDiclofenac/Misoprostol50 mg/200 mcg$51.99
drug typeDiclofenac/Misoprostol75 mg/200 mcg$61.99


Arthrotec Information

How And Where To Buy Arthrotec Online?


You can buy Arthrotec and Celebrex online through our Canadian International Pharmacy at huge savings. We offer RX and OTC medications online with a valid prescription from your doctor. At Canadian Pharmacy World, your health is our priority. You can place the order online, by mail, by fax or toll-free over the telephone at 1866-485-7979.

Are There Alternative Names For The Brand And Generic Arthrotec?


Arthrotec is available from Canada and United Kingdom manufactured by Pfizer Inc. The generic equivalent of Arthrotec is Diclofenac/Misoprostol and is manufactured in Canada by a different manufacturer.

What Dosages And Forms Is Arthrotec Available In?


Each branded as well as the generic form of Arthrotec tablet is available as 50 mg and 75 mg 50 mg diclofenac sodium, surrounded by an outer coating of 200 mcg of misoprostol. The packaging is supplied in the bottles of 250 tablets.

What Is Arthrotec Used For?


The medication Arthrotec is prescribed for short-term and long-term use in providing relief from signs and symptoms of rheumatoid arthritis and osteoarthritis. This medication contains two active ingredients: diclofenac and misoprostol. Diclofenac is a non-steroidal anti-inflammatory medication (NSAID) which acts as a painkiller, reduces joint pain, stiffness, and swelling by decreasing the production of prostaglandins and control inflammation. Misoprostol is a drug that protects the lining of the stomach as a NSAID can cause damage to your stomach. Misoprostol replaces the prostaglandins that are lost when taking the NSAID medicine. It protects the thick mucus layer and reduces the acid in your stomach. This can help to protect your stomach from the NSAID. Arthrotec does not cure the illness or prevent it from worsening, but rather promotes suppression of inflammation and tissue-damaging effects resulting from inflammation. This medication can only relieve pain and reduce swelling as long as you continue to take it.

What Are The Possible Side Effects Of Arthrotec?


Arthrotec can lead to some undesirable reactions especially when used for a long time and in large doses. The common side effects of Arthrotec include drowsiness, tiredness, increased sensitivity to sunlight, sunburn, skin rash, skin blisters, redness, itching, or discoloration and vision changes on exposure to sunlight or sunlamps. In case you get a reaction from the sun, consult your healthcare provider immediately. Immediately consult your health care provider if you develop:

• Chills
• Fever
• Muscle pain
• Other flu-like symptoms, especially if they occur before or together with a skin rash.

The most common side effect of this medication is stomach upset such as indigestion, nausea, vomiting, stomach pain or diarrhea. Since misoprostol causes increased production of mucus, some patients might experience diarrhea. It is just a sign that the medicine is working. Usually, diarrhea goes away in two to three days, but if it persists for a week or more, contacts your doctor. While your body gets used to misoprostol, you may feel crampy pain in your stomach.

Some of the serious side effects of Arthrotec include bloody or black tarry stools, vomiting blood, shortness of breath, wheezing, tightness in chest, skin rash, hives, blurred vision, change in the amount or color of urine, jaundice, change in heart rate, change in blood pressure, heart failure, blood clot, blood infection, lung infection, dreams, seizures, changes in mood, Benign mass in the intestine, trouble with swallowing, pain while urinating, weight gain, swelling of lower legs, tiredness, loss of appetite and stiff neck, dizziness, light-headedness, hearing problems, agranulocytosis (with fever, chills, sore throat or mouth sores, flu-like symptoms, weakness), increased sensitivity or nerve pain and anemia. These are not all the possible side effects of Arthrotec. In case of any unexpected effect, contact your doctor immediately.

Are there any Precautions and Drug interactions for Arthrotec?


It is important to be cautious about driving or participating in activities that require alertness if you are drowsy, dizzy or lightheaded after taking this medication. Moreover, do not drink alcoholic beverages while taking this medication because you are more likely to develop stomach problems. This medication should not be used with other NSAIDs such as ibuprofen.

Do not take Arthrotec, if you:

• Are allergic to diclofenac or misoprostol or any other ingredients present in the medication
• Have or had heart bypass surgery

• Suffer from severe uncontrolled heart failure
• Suffer from bleeding in the brain or other bleeding disorders
• Are pregnant or planning to become pregnant
• Are breastfeeding or plan to breastfeed
• Are allergic to any other NSAID
• Suffer from bleeding in the stomach or gut
• Have been diagnosed with Inflammatory bowel disease (Crohn’s Disease or Ulcerative Colitis)
• Have liver failure
• Have kidney diseases
• Have high levels of potassium in your blood

Arthrotec should not be used in children under 18 years of age as the safety and efficacy of this medication have not been established in this population.

In case you have or had any following conditions, be sure to see your healthcare professional to discuss options other than Arthrotec:

• Heart Attack or Angina
• Stroke or Mini-stroke
• Loss of Vision
• Congestive Heart Failure
• Current Pregnancy
• High blood pressure
• Diabetes
• High levels of fats in your blood
• Smoking

It is important to take the lowest dose of Arthrotec that can relieve pain or swell and for the shortest period of time. Before taking Arthrotec, consult your healthcare provider if you:

• Have disease of the heart or blood vessels
• Have uncontrolled high blood pressure, congestive heart failure, established ischemic disease or peripheral artery disease
• Are at the risk of any cardiovascular disease such as abnormally high levels of fat, diabetes, or smoking
• Have diabetes mellitus or on a low sugar diet
• Have atherosclerosis
• Have poor circulation of blood to your limbs
• Are a smoker or an ex-smoker
• Have kidney disease or urine problems
• Have the previous ulcer or bleeding from the stomach or gut
• Have had previous bleeding in the brain
• Have bleeding problems
• Family history of allergy to NSAIDs, such as acetylsalicylic acid (ASA), celecoxib, diclofenac, diflunisal, etodolac, fenoprofen, flurbiprofen, ibuprofen, indomethacin, ketoprofen, ketorolac, mefenamic acid, meloxicam, nabumetone, naproxen, oxaprozin, piroxicam, rofecoxib, sulindac, tenoxicam, tiaprofenic acid, tolmetin, or valdecoxib (NOT a complete list

• Have a family history of asthma, nasal polyps, long-term swelling of the sinus (chronic sinusitis) or hives
• Are on any special diet such as low sodium diet
• Drink alcohol
• Have difficulty in conceiving

Drug interactions


You should always tell your health care professional about any medications that you have been taking or are going to take including prescription and non-prescription drugs, vitamins and herbal supplements. Some of the medications that can interact with Arthrotec include:

• Acetylsalicylic Acid (ASA) or other NSAIDs (e.g. ASA, celecoxib, diclofenac, ibuprofen, indomethacin, ketorolac, meloxicam, naproxen)
• Antacids
• Antidepressants such as Selective Serotonin Reuptake Inhibitors (SSRIs) (e.g. citalopram, fluoxetine, paroxetine, sertraline)
• Blood pressure medications like Diuretics (e.g. furosemide, hydrochlorothiazide), ACE (Angiotensin converting enzyme) inhibitors (e.g. enalapril, lisinopril, perindopril, ramipril), ARBs (angiotensin II receptor blockers) (e.g. candesartan, irbesartan, losartan, valsartan), Beta-blockers
• Blood thinners like warfarin ASA, clopidogrel
• Corticosteroids (including glucocorticoids) (e.g. prednisone)
• Cyclosporine (a medication used to prevent organ rejection after transplants)
• Digoxin (the drug used to treat abnormal heartbeats)
• Lithium (used to treat bipolar disorder and mania)
• Methotrexate (an anti-cancer medication)
• Oral contraceptives
• Anti-diabetic medications
• Phenytoin (a medicine used to treat seizures)
• Tacrolimus (a medication used to prevent organ rejection after transplants)
• Sulfinpyrazone (a medicine used to treat gout)
• Voriconazole (a medicine used to treat fungal infections)

Arthrotec Storage and Safety Information


Arthrotec should be stored at a temperature between 15-25°C, protected from heat and humidity. Keep the medication out of sight and reach of children.

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The content on this page has been supplied to canadianpharmacyworld.com by an independent third party contracted to provide information for our website. Canadianpharmacyworld.com relies on these third parties to create and maintain this information and cannot guarantee the accuracy or reliability of the information that has been provided to us.

The drug information provided here is only a summary and does not contain all the list of possible side effects and drug interactions regarding this medication. Be sure to contact your doctor or pharmacist if you have any specific question or concern. If you require any advice or information about the drugs on this page, a medical condition or treatment advice, you should always speak to a healthcare professional.

Please note that not all products, including any referenced in this page, are shipped by our affiliated Canadian Pharmacy. We are affiliated with other dispensaries that ship product to our customers from the following jurisdictions: Canada, Singapore, New Zealand, Turkey, Mauritius, India, and United Kingdom. The items in your order maybe shipped from any of the above jurisdictions. The products are sourced from various countries as well as those listed above. Rest assured, we only affiliate with our authorized dispensaries that procure product through reliable sources.

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Prescriptions dispensed from Canada are dispensed by: Candrug Pharmacy, ID#18985 604-543-8711. Pharmacy Manager: Carol Hou. Pharmacy Address: Unit #202A, 8322-130th Street, Surrey, British Columbia, Canada V3W 8J9. This pharmacy is duly licensed in the province of British Columbia, Canada by the College of Pharmacists of BC. If you have any questions or concerns you can contact the college at: 200-1765 West 8th Ave Vancouver, BC V6J 5C6 Canada.
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