* The product images are for reference only. Generic equivalents may also be supplied by alternate manufacturers.
Ordering Advair Diskus (Fluticasone/Salmeterol)
At CanadianPharmacyWorld, we provide quick and affordable access to your medication. With a valid prescription from a US-licensed physician, you can order this through our licensed pharmacy for direct-to-door delivery. We prioritize safety and significant savings on every order. Learn more about our standards on our
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What is Advair Diskus?
This is a combination medication containing an inhaled corticosteroid (fluticasone) and a long-acting beta-agonist (salmeterol). It is used to prevent asthma attacks and manage symptoms such as wheezing and shortness of breath caused by asthma or chronic obstructive pulmonary disease (COPD)."It works by opening the airways in the lungs, making breathing easier for adults and children aged 4 and older. Do not use it to relieve sudden breathing problems, and it won't replace a rescue inhaler. You may buy Albuterol to relieve symptoms of a sudden asthma attack.
The brand Advair Diskus is available in Turkey and India under the name Seretide Accuhaler. We also offer the generic fluticasone/salmeterol Diskus, available in India as Seroflo.
Available Strengths and Sizes
The brand name and generic versions are available in 100/50 mcg/60-dose, 250/50 mcg/60-dose, and 500/50 mcg/60-dose Diskus.
Adverse Reactions & Side Effects
Common Side Effects – If these persist or become a concern, please reach out to your healthcare provider:
• Cough
• Dizziness
• Headache
• Hoarseness or voice changes
• Nausea and vomiting
• Sore throat
• Stuffy or runny nose
• Throat irritation
Other Potential Side Effects (less common) - The following list includes side effects that are reported less frequently by individuals:
• Bronchitis
• Muscle and bone pain
• Oral candidiasis (thrush)—white patches in the mouth or throat
• Palpitations or rapid heartbeat
• Sinus pain
• Sleep disturbances
• Tremors or nervousness
• Upper respiratory tract infection
Serious Side Effects – These reactions are rare but require immediate medical attention. Stop using the medication and call your doctor or emergency services if you experience:
• Cardiovascular effects
• Eye problems
• Hypersensitivity reactions
• Paradoxical bronchospasm
• Pneumonia
Note: Ask your doctor to monitor you for long-term risks, such as decreased bone mineral density or, in children, reduced growth velocity.
Contraindications
Do NOT take this medication if any of the following conditions exist:
• Acute Asthma or COPD Episodes: an occurrence of acute bronchospasm or status asthmaticus where intensive measures are required.
• Hypersensitivity: known allergy to fluticasone propionate, salmeterol, or any of the excipients, specifically milk proteins (because Diskus contains lactose).
• Primary Treatment of Status Asthmaticus: Requires emergency intervention for which a long-acting beta-agonist (LABA) and inhaled corticosteroid (ICS) combination is inappropriate.
Precautions & Warnings
The following conditions warrant a detailed discussion with a healthcare provider before starting this medication, as they may need to be adjusted or avoided to ensure patient safety:
• Cardiovascular Disorders: Cardiac arrhythmias, coronary insufficiency, or hypertension, because the salmeterol component may cause clinically significant cardiovascular effects.
• Convulsive Disorders: History of seizures or epilepsy.
• Diabetes Mellitus: Pre-existing diabetes, as inhaled corticosteroids and beta-agonists can occasionally raise blood glucose levels.
• Hepatic Impairment: Liver disease may lead to the accumulation of fluticasone and salmeterol in the plasma.
• Hyperthyroidism: Overactive thyroid conditions.
• Immunosuppression: Existing infections (viral, bacterial, fungal, or parasitic) or recent exposure to measles or chickenpox, because corticosteroids can suppress the immune response.
• Ocular Changes: History of glaucoma, increased intraocular pressure, or cataracts.
• Osteoporosis: Risk factors for decreased bone mineral density include prolonged immobilization and a family history of bone loss.
Drug Interactions
Understanding how Advair interacts with other substances is crucial for safe and effective treatment. The following medications may need close monitoring or dosage adjustments when taken together.
• Beta-Blockers: Medications such as atenolol, metoprolol, or propranolol (including eye drops for glaucoma) can block salmeterol's effects. This may result in loss of therapeutic effect or severe bronchospasm in patients with asthma or COPD.
• CYP3A4 Inhibitors: Potent inhibitors—including atazanavir, clarithromycin, indinavir, itraconazole, ketoconazole, nefazodone, nelfinavir, ritonavir, saquinavir, and telithromycin—can increase systemic fluticasone propionate concentrations. This increase raises the risk of systemic corticosteroid side effects, such as Cushing’s syndrome and adrenal suppression.
• Diuretics: Non-potassium-sparing diuretics (such as furosemide or hydrochlorothiazide) may have their potassium-lowering effects intensified when used with a beta-agonist such as salmeterol. This interaction can lead to significant hypokalemia and ECG changes.
• Monoamine Oxidase Inhibitors (MAOIs) and Tricyclic Antidepressants: Drugs such as selegiline, phenelzine, amitriptyline, and imipramine can increase salmeterol's effects on the vascular system. These agents should be used with extreme caution or avoided for 2 weeks after discontinuation to prevent severe cardiovascular reactions.
Other Notable Interactions:• Antifungal Agents: Systemic azole antifungals can increase plasma levels of both components of Advair, potentially leading to increased cardiovascular strain or immunosuppression.
• Other Long-Acting Beta-Agonists (LABAs): Advair should not be used with other medications containing LABAs (such as formoterol or vilanterol) because of the cumulative risk of cardiovascular side effects and overdose.
Safety & Storage Information
Advair Diskus should be stored at room temperature, away from heat and direct light. Please do not freeze it. You should not keep this medication in a car, where it could be exposed to extreme heat or cold. Do not keep expired medication.
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Infographic: Best-Value Asthma Drugs for 2019 RevealedHow to Get the Most Out of Your Asthma InhalersThe content on this page has been supplied to canadianpharmacyworld.com by an independent third party contracted to provide information for our website. Canadianpharmacyworld.com relies on these third parties to create and maintain this information and cannot guarantee the accuracy or reliability of the information that has been provided to us.
The drug information provided here is only a summary and does not contain all the list of possible side effects and drug interactions regarding this medication. Be sure to contact your doctor or pharmacist if you have any specific question or concern. If you require any advice or information about the drugs on this page, a medical condition or treatment advice, you should always speak to a healthcare professional.
Please note that not all products, including any referenced in this page, are shipped by our affiliated Canadian Pharmacy. We are affiliated with other dispensaries that ship product to our customers from the following jurisdictions: Canada, Singapore, New Zealand, Turkey, Mauritius, India, and United Kingdom. The items in your order maybe shipped from any of the above jurisdictions. The products are sourced from various countries as well as those listed above. Rest assured, we only affiliate with our authorized dispensaries that procure product through reliable sources.