* The product images are for reference only. Generic equivalents may also be supplied by alternate manufacturers.
Ordering Colchicine (The Generic version of Colcrys)
At CanadianPharmacyWorld, we provide quick and affordable access to your medication. With a valid prescription from a US-licensed physician, you can order this through our licensed pharmacy for direct-to-door delivery. We prioritize safety and significant savings on every order. Learn more about our standards on our About Us page.
What is Colcrys?
This prescription medication is used to prevent or treat gout flares. It may also be used to treat Familial Mediterranean Fever (FMF). Gout is caused by excess uric acid in the blood, which forms crystals in the joints. This medication works by reducing the inflammation and swelling caused by these crystals. It may also be used to reduce swelling and inflammation of the sac that covers the heart, a condition called pericarditis.
The brand Colcrys is currently unavailable. The generic Colchicine 0.5 mg is produced in the United Kingdom and Turkey. It is also known as Kolsin. The generic Colchicine 0.6 comes from Canada by different manufacturers.
Available Strengths and Sizes
Colchicine is available in 0.5mg and 0.6mg tablet strengths.
Adverse Reactions & Side Effects
Common Side Effects – If these persist or become a concern, please reach out to your healthcare provider:
• Abdominal pain or cramping
• Diarrhea (reported in over 20% of patients)
• Nausea
• Vomiting
Other Potential Side Effects (less common) - The following list includes side effects that are reported less frequently by individuals:
• Alopecia (hair loss or thinning)
• Fatigue
• Headache
• Loss of appetite
• Sore throat (pharyngolaryngeal pain)
Serious Side Effects – These reactions are rare but require immediate medical attention. Stop using the medication and call your doctor or emergency services if you experience:
• Agranulocytosis (severe reduction in white blood cell count)
• Anaphylaxis (severe hypersensitivity reaction)
• Hepatotoxicity (liver damage)
• Myopathy or Rhabdomyolysis (muscle weakness or breakdown)
• Neuromuscular Toxicity
Contraindications
Do NOT take this medication if any of the following conditions exist:
• Hypersensitivity: A known allergy or hypersensitivity to this drug or any inactive ingredients in the tablet formulation.
• P-gp or Strong CYP3A4 Inhibitors with Renal/Hepatic Impairment: Renal or hepatic impairment and concurrent use of potent CYP3A4 inhibitors (like clarithromycin) or P-glycoprotein (P-gp) inhibitors (like cyclosporine).
• Severe Renal or Hepatic Failure: End-stage renal disease requiring dialysis or severe hepatic failure, particularly when the medication is used for gout flare prophylaxis.
Precautions and Warnings
The following conditions warrant a detailed discussion with a healthcare provider before starting this medication, as they may need to be adjusted or avoided to ensure patient safety:
• Alcohol Use: Chronic alcohol consumption may increase the risk of gastrointestinal side effects and affect uric acid levels.
• Blood Disorders: History of blood dyscrasias, such as anemia or low white blood cell counts.
• Kidney Disease: Renal impairment, as dosage adjustments are often necessary to prevent toxicity.
• Liver Problems Liver disease, which can affect how the body metabolizes the drug.
• Neuromuscular Disease Conditions like myasthenia gravis, as this drug can increase the risk of muscle toxicity.
Drug Interactions
Understanding how Colchicine interacts with other substances is crucial for safe and effective treatment. The following medications may need close monitoring or dosage adjustments when taken together.
• CYP3A4 Inhibitors: Medications such as clarithromycin, erythromycin, ketoconazole, and ritonavir can significantly increase colchicine levels in the blood, leading to life-threatening toxicity.
• HMG-CoA Reductase Inhibitors (Statins): Taking this medication with statins like atorvastatin or simvastatin may increase the risk of muscle pain and breakdown (rhabdomyolysis).
• P-glycoprotein (P-gp) Inhibitors: Drugs like cyclosporine or ranolazine can interfere with the transport of colchicine, increasing its concentration and the potential for adverse effects.
Other Notable Interactions• Digoxin: Concurrent use may increase the risk of myopathy from colchicine.
• Fibrates: Medications such as gemfibrozil may also increase the risk of muscle-related side effects when combined with colchicine.
• Grapefruit Juice: This can inhibit the metabolism of this drug and should generally be avoided during treatment.
Safety & Storage Information
This medication should be stored at room temperature, away from light and moisture, and out of reach of children and pets. This medication should not be stored in the bathroom.
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Understanding the Link between Gout Flares and Heart Disease ComplicationsThe content on this page has been supplied to canadianpharmacyworld.com by an independent third party contracted to provide information for our website. Canadianpharmacyworld.com relies on these third parties to create and maintain this information and cannot guarantee the accuracy or reliability of the information that has been provided to us.
The drug information provided here is only a summary and does not contain all the list of possible side effects and drug interactions regarding this medication. Be sure to contact your doctor or pharmacist if you have any specific question or concern. If you require any advice or information about the drugs on this page, a medical condition or treatment advice, you should always speak to a healthcare professional.
Please note that not all products, including any referenced in this page, are shipped by our affiliated Canadian Pharmacy. We are affiliated with other dispensaries that ship product to our customers from the following jurisdictions: Canada, Singapore, New Zealand, Turkey, Mauritius, India, and United Kingdom. The items in your order maybe shipped from any of the above jurisdictions. The products are sourced from various countries as well as those listed above. Rest assured, we only affiliate with our authorized dispensaries that procure product through reliable sources.