* The product images are for reference only. Generic equivalents may also be supplied by alternate manufacturers.
Ordering Premarin Vaginal Cream (Conjugated Estrogens)
At CanadianPharmacyWorld, we provide quick and affordable access to your medication. With a valid prescription from a US-licensed physician, you can order this through our licensed pharmacy for direct-to-door delivery. We prioritize safety and significant savings on every order. Learn more about our standards on our About Us page.
What is Premarin Vaginal Cream?
This prescription hormone medication is primarily used to treat menopausal vaginal symptoms, including atrophic vaginitis and kraurosis vulvae. It contains conjugated estrogens to help restore vaginal tissue health. During menopause, estrogen production declines, leading to symptoms such as vaginal dryness, burning, itching, and painful sexual intercourse. By locally replacing these hormones, Premarin helps reduce discomfort and improve tissue elasticity.
The brand-name vaginal cream Premarin is manufactured by Pfizer in Canada and India.
Available Strengths and Sizes
Premarin Vaginal Cream is available in 14 gm and 30 gm doses. Generic Conjugated Estrogens cream is currently not available.
Adverse Reactions & Side Effects
Common Side Effects – If these persist or become a concern, please reach out to your healthcare provider:
• Abdominal cramps
• Back pain
• Bloating
• Breast tenderness or enlargement
• Headache
• Nausea
• Vaginal discomfort or itching
• Vaginal yeast infection (candidiasis)
Other Potential Side Effects (less common) - The following list includes side effects that are reported less frequently by individuals:
• Changes in sexual drive (libido)
• Dizziness
• Hair loss (alopecia)
• Increased blood pressure
• Mood swings or irritability
• Nervousness
• Skin rash or darkening of facial skin (chloasma)
• Weight changes
Serious Side Effects – These reactions are rare but require immediate medical attention. Stop using the medication and call your doctor or emergency services if you experience:
• Cardiovascular Complications (stroke or heart attack symptoms)
• Deep Vein Thrombosis (leg pain, swelling, or redness)
• Hepatic Impairment (yellowing of eyes/skin)
• Hypersensitivity Reactions
• Pulmonary Embolism (sudden shortness of breath)
• Undiagnosed vaginal bleeding
Contraindications
Do NOT take this medication if any of the following conditions exist:
• Hypersensitivity: a known allergy or hypersensitivity to conjugated estrogens or any of the inactive ingredients in the cream base.
• Known or Suspected Pregnancy: a confirmed or suspected pregnancy, as estrogens may cause fetal harm.
• Known or Suspected Estrogen-Dependent Neoplasia: breast cancer or any other estrogen-dependent cancer (known or suspected).
• Thromboembolic Disorders: a history of or active deep vein thrombosis, pulmonary embolism, or active arterial thromboembolic disease (e.g., stroke or myocardial infarction).
• Undiagnosed Abnormal Genital Bleeding: vaginal bleeding that a physician has not evaluated.
Precautions and Warnings
The following conditions warrant a detailed discussion with a healthcare provider before starting this medication, as they may need to be adjusted or avoided to ensure patient safety:
• Asthma: Estrogen therapy may affect respiratory sensitivity.
• Diabetes Mellitus: can affect blood glucose levels.
• Endometriosis: history of uterine fibroids.
• Gallbladder Disease: History of gallbladder problems or of cholestatic jaundice.
• Heart Disease or Hypertension: High blood pressure or risk factors for heart disease.
• Kidney or Liver Problems: History of renal or hepatic impairment.
• Thyroid Disease: Hypothyroidism, as estrogen may interfere with thyroid hormone replacement therapy.
Drug Interactions
Understanding how Premarin interacts with other substances is crucial for safe and effective treatment. The following medications may need close monitoring or dosage adjustments when taken together.
• Anticoagulants: Estrogens may reduce the effectiveness of anticoagulants such as warfarin. Close monitoring of prothrombin time and INR is necessary for patients on combined therapy.
• CYP3A4 Inducers: Medications such as rifampin, carbamazepine, or St. John's Wort can increase the metabolism of estrogens, potentially reducing their clinical effectiveness and altering uterine bleeding patterns.
• CYP3A4 Inhibitors: Drugs such as clarithromycin and erythromycin, or grapefruit juice, may inhibit estrogen metabolism, leading to increased blood levels and a higher risk of side effects.
• Thyroid Replacement Therapy: Estrogens can increase thyroid-binding globulin levels. Patients receiving thyroid hormone replacement may need higher doses to maintain normal free thyroid hormone levels.
Other Notable Interaction• Corticosteroids: Estrogens may increase the effects of corticosteroids. Dosage adjustments may be needed if signs of corticosteroid excess develop.
• Vaginal Products: Using other vaginal products (such as douches, spermicides, or other creams) at the same time as Premarin may interfere with the medication's absorption or effectiveness. It is generally recommended to avoid other vaginal treatments during this time.
Safety & Storage Information
Premarin Vaginal Cream should be stored at room temperature, away from light and moisture, and out of reach of children and pets. Do not store this medication in the bathroom. Keep the tube tightly capped after each use.
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7 Ways to Support A Loved One Through MenopauseThe content on this page has been supplied to canadianpharmacyworld.com by an independent third party contracted to provide information for our website. Canadianpharmacyworld.com relies on these third parties to create and maintain this information and cannot guarantee the accuracy or reliability of the information that has been provided to us.
The drug information provided here is only a summary and does not contain all the list of possible side effects and drug interactions regarding this medication. Be sure to contact your doctor or pharmacist if you have any specific question or concern. If you require any advice or information about the drugs on this page, a medical condition or treatment advice, you should always speak to a healthcare professional.
Please note that not all products, including any referenced in this page, are shipped by our affiliated Canadian Pharmacy. We are affiliated with other dispensaries that ship product to our customers from the following jurisdictions: Canada, Singapore, New Zealand, Turkey, Mauritius, India, and United Kingdom. The items in your order maybe shipped from any of the above jurisdictions. The products are sourced from various countries as well as those listed above. Rest assured, we only affiliate with our authorized dispensaries that procure product through reliable sources.