Buy Activella (Estradiol/Norethindrone Acetate)

TypeDrug NameDosagePrice from 
drug typeActivella0.5 mg/0.1 mg$281.99
drug typeActivella1 mg/0.5 mg$63.99


Activella Information

reviewed by reviwer portrait Dr. Bolanle Aina, Pharmacist on 1/26/2022 9:56:53 AM.

How and Where to Buy Activella Online?


You can buy Activella online through our Canadian International Pharmacy at huge savings. Canadian Pharmacy World also offers other medications for Women’s Health. We offer RX and OTC medications online with a valid prescription from your doctor. At Canadian Pharmacy World, your health is our priority. You can place the order online, by mail, by fax or toll-free over the telephone at 1866-485-7979.

Are There Alternative Names for the Brand and Generic Activella?


Activella is available from Canada and Turkey by Novo Nordisk. The generic form of Activella is Estradiol and Norethindrone acetate which is not available at this time.

What Dosages and Forms is Activella available in?


Activella is available in dosage forms of 0.5 mg/0.1 mg and 1 mg/0.5 mg as estradiol/ norethindrone acetate. The tablets are available in calendar dial packs of 1x28 tablets or 3x28 tablets.

What Is Activella used for?


The medication Activella is used for the treatment of moderate to severe vasomotor symptoms (uncomfortable feelings of heat, flushing, and sweating) that occur in women after menopause due to lower estrogen levels. It is also used to treat vulvar and vaginal atrophy (changes on the vagina or external genital organs due to low estrogen levels associated with menopause), with symptoms such as itching, burning, dryness in or around the vagina, difficulty or burning during urination and pain while having sex. The estradiol in Activella is an estrogen hormone and helps to relieve menopausal symptoms. Activella replaces the estrogen in the body which decreases naturally after menopause. The progestin hormone called norethindrone acetate (NETA) helps to reduce the risk of cancer of the uterus. This medication should be used only under the supervision of a doctor with regular follow-ups at least once a year to find out the side effects associated with its use. Your visit may include a blood pressure check, a pap smear, pelvic exam and a mammogram.

What Are The Possible Side Effects of Activella?


Some of the most common side effects caused by Activella include headache, irregular vaginal bleeding or spotting during the first 3-6 months of treatment (in case bleeding continues or starts after 6 months, consult your doctor immediately), changes in amount of cervical secretions, vaginal itching, breast pain, tenderness, swelling and enlargement, hot flushes, bloating, uterine fibroids, involuntary muscle spasms, leg cramps, heartburn, increase or decrease in weight, hair loss or abnormal hair growth, acne, discoloration of skin especially of the face, or neck (known as pregnancy patches), red or purple discoloration of skin and mucus membranes, painful reddish skin nodules. Some of the serious side effects of Activella include abdominal pain, nausea, vomiting, swelling of arms and legs, depression, genital infection, endometrial thickening, allergic reaction, unexpected vaginal bleeding, heart attack, blood clots in legs, lungs or eyes, stroke, jaundice, inflammation of a vein, increase in blood pressure, gallbladder disease and migraine. These are not all the possible side effects of Activella. In case of any unexpected effect, contact your healthcare professional immediately.

Are there any Precautions and Drug interactions for Activella?


Activella is not a contraceptive. If it is less than 12 months since your last menstrual period or you are under 50 years old, you may still need to use additional contraception to prevent pregnancy. Speak to your doctor for advice. If you are going to have surgery, tell the surgeon that you are taking Activella. You may need to stop taking Activella at least 4 to 6 weeks before the operation to reduce the risk of a blood clot. Ask your doctor when you can start taking Activella again.

Do not use Activella if you:

• Are allergic to this medication or any of its ingredients or components of the container

• Have liver disease or have abnormal liver function tests

• Have known suspected or past history of estrogen-dependent or progestin-dependent endometrial cancer

• Have excessive thickening of the uterus lining

• Have known, suspected or past history of breast cancer

• Have unexplained vaginal bleeding

• Are pregnant or might become pregnant

• Are breastfeeding

• Have a disease caused by blood clots in the arteries such as a heart attack, stroke. Or angina

• Have or ever had a blood clot in a vein such as a leg or lungs

• Have complete or partial loss of vision

• Have porphyria (a disease of blood pigments)

• Have a migraine

If any of the above conditions appear for the first time while taking Activella, stop taking the medication and consult your healthcare professional immediately.

Before using Activella talk to your healthcare professional in case you:

• Have a history of allergy or intolerance to any medications or food

• Have a personal history of breast cancer (including breast lumps) or breast biopsies or a family history of breast cancer

• Have experienced unusual or undiagnosed vaginal bleeding

• Have a history of uterine fibroids or history of excessive growth of uterus lining

• Have a history of liver disease or liver tumors, jaundice or itching related to estrogen use or during pregnancy

• Have a history of migraine headaches

• Have a history of high blood pressure

• Have a history of blood clots, or heart disease or stroke

• Have a history of kidney disease, asthma or epilepsy

• Have gallbladder disease

• Have a history of bone disease (including certain metabolic conditions or cancers that can affect blood levels of calcium and phosphorus)

• Have a condition where the thyroid gland fails to produce enough thyroid hormone and you are being treated with thyroid hormone replacement therapy

• Have been told that you have a condition called hereditary angioedema (have episodes of rapid swelling of hands, feet, lips, eyes, face, tongue, throat, digestive tract)

• Have been diagnosed with lupus

• Have diabetes

• Have porphyria (a disease of blood pigment)• Have a history of high cholesterol or high triglycerides

• Have very low calcium levels

• Have been diagnosed with depression

• Have been at prolonged bed rest

• Are pregnant or might become pregnant

• Are breastfeeding

• Have had surgical removal of the uterus

• Have a disease that affects the eardrum and hearing called as otosclerosis

• Have lactose intolerance

• Smoke

Drug interactions


You should tell your healthcare professional about all the medications and skin products that you use, including any prescription or non-prescription vitamins or herbal supplements. Medications which can interact with Activella include:

• Medications used for the treatment of epilepsy such as phenobarbital, hydantoin, phenytoin, and carbamazepine

• Drugs used to treat tuberculosis such as rifampicin and rifabutin

• Drugs used to treat HIV or hepatitis infections such as nevirapine, efavirenz, ritonavir, telaprevir, and nelfinavir

• Anticoagulant medications such as warfarin

• Drugs used to lower blood pressure such as propranolol

• Drugs used to treat diabetes such as metformin

• Barbiturates

• Herbal preparations containing St. John’s Wort

• Ketoconazole (an antifungal medicine)

• Grapefruit juice may increase the effect of Activella

Activella Storage and Safety Information


The medication should be stored at a room temperature between 15°C and 25°C, away from heat and humidity. Store in a dry place, protected from light by keeping the dial pack inside the original carton. Do not store the calendar dial pack in the refrigerator. Keep this medicine out of sight and reach of children.

The content on this page has been supplied to canadianpharmacyworld.com by an independent third party contracted to provide information for our website. Canadianpharmacyworld.com relies on these third parties to create and maintain this information and cannot guarantee the accuracy or reliability of the information that has been provided to us.

The drug information provided here is only a summary and does not contain all the list of possible side effects and drug interactions regarding this medication. Be sure to contact your doctor or pharmacist if you have any specific question or concern. If you require any advice or information about the drugs on this page, a medical condition or treatment advice, you should always speak to a healthcare professional.

Please note that not all products, including any referenced in this page, are shipped by our affiliated Canadian Pharmacy. We are affiliated with other dispensaries that ship product to our customers from the following jurisdictions: Canada, Singapore, New Zealand, Turkey, Mauritius, India, and United Kingdom. The items in your order maybe shipped from any of the above jurisdictions. The products are sourced from various countries as well as those listed above. Rest assured, we only affiliate with our authorized dispensaries that procure product through reliable sources.

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Prescriptions dispensed from Canada are dispensed by: Candrug Pharmacy, ID#18985 604-543-8711. Pharmacy Manager: Carol Hou. Pharmacy Address: Unit #202A, 8322-130th Street, Surrey, British Columbia, Canada V3W 8J9. This pharmacy is duly licensed in the province of British Columbia, Canada by the College of Pharmacists of BC. If you have any questions or concerns you can contact the college at: 200-1765 West 8th Ave Vancouver, BC V6J 5C6 Canada.
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