* The product images are for reference only. Generic equivalents may also be supplied by alternate manufacturers.
How and Where to Buy Activelle Online?
You can buy Activelle and other
Women's Health medications online through our Canadian International Pharmacy at huge savings. We offer RX and OTC medications online with a valid prescription from your doctor. At Canadian Pharmacy World, your health is our priority. You can place the order online, by mail, by fax or toll-free over the telephone at 1866-485-7979.
Are There Alternative Names for the Brand and Generic Activelle?
Activelle comes from Canada and is manufactured by Novo Nordisk. The active ingredients in Activelle are Estradiol and Norethindrone Acetate. The generic form of Activelle is not available.
What Dosages and Forms is Activelle available in?
Activelle is available as film-coated tablets in two dosage forms Activelle and Activelle LD. Activelle contains 1 mg estradiol and 0.5 mg norethindrone acetate. Activelle LD contains 0.5 mg estradiol and 0.1 mg norethindrone acetate
What is Activelle used for?
Activelle and Activelle LD is used to treat moderate to severe vasomotor symptoms (uncomfortable feelings of heat, sweating and flushing) that can occur as a result of low estrogen levels associated with menopause. Activelle is also used to treat vulval and vaginal atrophy (changes in the vagina or external genitalia as a result of low estrogen levels associated with menopause) with symptoms such as itching, burning, dryness in or around vagina, difficulty or burning while urination, and pain while having sex. The estrogen hormone is called estradiol (E2) and helps to relieve your menopausal symptoms. Estradiol is identical to the estrogen produced naturally by your body. Activelle replaces the estrogen in your body, which decreases naturally at menopause. The progestin hormone is called norethindrone acetate (NETA) and helps to reduce the risk of endometrial hyperplasia (stimulation of growth of the lining of the uterus), which could lead to cancer of the lining of the uterus (womb). Activelle and Activelle LD should be used only in women with intact uterus. Activelle and Activelle LD should be used only under the supervision of a doctor, with regular follow-up at least once a year to identify side effects associated with its use. Your first follow-up visit should be within 3to 6 months of start of treatment. Your visit may include a blood pressure check, a breast exam, a Pap smear and pelvic exam. You should have a mammogram before starting treatment and at regular intervals as recommended by your doctor. Your doctor may recommend some blood tests. Activelle and Activelle LD is supplied in calendar dial packs of 28 white tablets. Take one tablet once daily. Try to take the medication at the same time each day. Once you have finished all the 28 tablets in the pack, start a new pack continuing the treatment without interruption.
What Are The Possible Side Effects of Activelle?
Some of the common side effects of this medication include headache, irregular vaginal bleeding or spotting during the first 6 months of treatment, change in the amount of cervical secretion, vaginal and genital itching, breast pain or tenderness, swelling and enlargement, hot flushes, bloating, uterine fibroids, back or neck pain, involuntary muscle spasms, leg cramps, heartburn, increase or decrease in weight, hair loss or abnormal hairiness, acne, discoloration of the skin especially around the face or neck, known as pregnancy patches, red or purple discolorations of the skin, painful reddish skin nodules, abdominal pain, nausea, vomiting. Some of he serious side effects of this medication include swelling of arms and legs, depression, genital infection with a fungus or vaginal inflammation, enlargement of the lining of womb, allergic reaction, unexpected vaginal bleeding, rash with target-shaped reddening or sores, heart attack, blood clot in legs, lungs and eyes, jaundice, stroke, inflammation of vein, increase in blood pressure, gallstones or gallbladder disease, and migraine. These are not all the possible side effects of Activelle. In case of any unexpected effect, consult your healthcare professional immediately.
Are there any Precautions and Drug interactions for Activelle?
There is an increased risk of developing invasive breast cancer, heart attack, stroke and blood clots in both lungs and large veins with the use of estrogen plus progestin therapy. There is an increased risk of stroke and blood clots in the large veins with the use of estrogen-alone therapy.
Do not take Activelle if you:
• Are allergic to any ingredients in the medication
• Have liver disease
• Have known, suspected, or past history of estrogen-dependent or progestin-dependent malignant neoplasia (e.g. endometrial cancer
• Have excessive thickening of the womb lining (endometrial hyperplasia)
• Have known, suspected, or past history of breast cancer
• Have any unexplained vaginal bleeding
• Are or think you might be pregnant
• Are breastfeeding
• Have, or previously have had a disease caused by blood clots in the arteries, such as a heart attack, stroke or angina
• Have, or have ever had a blood clot in a vein such as in the legs or the lungs
• Have partial or complete loss of vision
• Have porphyria
• Have a migraine
If any of the above conditions appear for the first time while taking Activelle, stop taking it at once and consult your doctor immediately.
Before taking Activelle, inform your doctor if you:
• Have a personal history of breast disease or a family history of breast cancer
• Have experienced any unusual or undiagnosed vaginal bleeding
• Have a history of uterine fibroids or a history of excessive growth of the womb lining
• Have a history of liver disease or liver tumors, jaundice (yellowing of the eyes and/or skin) or itching related to estrogen use or during pregnancy
• Have a history of migraine headaches
• Have a history of high blood pressure
• Have a personal or family history of blood clots, or a personal history of heart disease or stroke
• Have a history of kidney disease, asthma or epilepsy (seizures)
• Have gallbladder disease
• Have a history of bone disease
• Have a condition where your thyroid gland fails to produce enough thyroid hormone (hypothyroidism) and you are treated with thyroid hormone replacement therapy
• Have been told that you have a condition called hereditary angioedema
• Have been diagnosed with lupus
• Have been diagnosed with diabetes
• Have been diagnosed with porphyria (a disease of blood pigment)
• Have a history of high cholesterol or high triglycerides
• Have very low calcium levels
• Have been diagnosed with depression
• Are on prolonged bed rest
• Have had a hysterectomy (surgical removal of the uterus)
• Have a disease affecting the eardrum and hearing (otosclerosis)
• Have lactose intolerance
• Smoke
Drug interactions
It is important to tell your healthcare professional about all other medicines that you have taken recently including any kind of supplements and non-prescription drugs.
Medications that can interact with Activelle include:
• Drugs used for the treatment of epilepsy (e.g. phenobarbital, phenytoin and carbamazepine)
• Drugs used for tuberculosis (e.g. rifampicin, rifabutin)
• Drugs used for the treatment of HIV or hepatitis infections (e.g. nevirapine, efavirenz, ritonavir)
• Anticoagulant, antidiabetic and antihypertensive drugs
• Barbiturates
• Herbal preparations containing St John’s Wort
• Ketoconazole (a fungicide)
• Grapefruit juice
Activelle Storage and Safety Information
The medication should be stored a temperature between 15-25°C, away from heat and humidity. It should be kept out of reach and sight of children.
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The drug information provided here is only a summary and does not contain all the list of possible side effects and drug interactions regarding this medication. Be sure to contact your doctor or pharmacist if you have any specific question or concern. If you require any advice or information about the drugs on this page, a medical condition or treatment advice, you should always speak to a healthcare professional.
Please note that not all products, including any referenced in this page, are shipped by our affiliated Canadian Pharmacy. We are affiliated with other dispensaries that ship product to our customers from the following jurisdictions: Canada, Singapore, New Zealand, Turkey, Mauritius, India, and United Kingdom. The items in your order maybe shipped from any of the above jurisdictions. The products are sourced from various countries as well as those listed above. Rest assured, we only affiliate with our authorized dispensaries that procure product through reliable sources.